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Hypertension:
According to the World Health Organization, nearly one billion people suffer from Hypertension. As one of the most important causes of premature death worldwide, an estimated 1.56 billion adults will be living with hypertension by the year 2025. Based on 2012 Statistical Fact Sheet on Hypertension by the American Heart Association, about 76.4 million people (age 20 and older) have high blood pressure condition, which could mean that there may be at least 7 to 11 million people with Primary Aldosteronism in the United States alone. Diagnosis and treatment of the underlying cause of their Hypertension could save and/or improve millions of lives - and save billions of dollars - every year.
The steroid hormone Aldosteroneis a potent mineral corticoid that is produced by the outer section (zona glomerulosa) of the adrenal cortex in the adrenal gland.
DRG has recently developed theAldosterone ELISA, an enzyme immunoassay for measurement of aldosterone in serum and plasma. Measurement of the Aldosterone levels in serum, in conjunction with plasma renin levels, can be used to differentiate between primary and secondary aldosteronism.
Renin, on the other hand, is a protein (Mw of 37 kDa) that belongs to the aspartic acid proteinase family of enzymes.
The DRG Renin ELISAis an enzyme immunoassay for quantitative measurement of active Renin in human EDTA plasma. Renin measurement can also be helpful in diagnosis and treatment of certain types of hypertension, such as hyperaldosteronism, malignant hypertonia (high blood pressure), etc.
Vitamin Deficiency:
Vitamin D is a prohormone that has long been known for its important role in regulating body levels of calcium and phosphorus and in mineralization of bone. Vitamin D plays a vital role in the formation and maintenance of strong healthy bones. However, in recent years,Vitamin D has become an assay of general health status, and there have been multiple publications linking Vitamin D deficiency to several diseases, such as cancer, diabetes, autoimmune and cardiovascular diseases, etc.
Vitamin D is unique in that it is made in the skin as a result of direct exposure to sunlight. Photosynthesis of vitamin D has been occurring on earth for more than 750 million years. Some of the earliest life forms that were exposed to sunlight for their energy requirement were also photosynthesizing vitamin D. Both children and adults have in the past depended on adequate sun exposure to satisfy their vitamin D requirement. It is well documented that at the turn of the last century, upwards of 80% of children in the industrialized, polluted cities of northern Europe and northeastern United States suffered from the devastating consequences of vitamin D deficiency rickets. The skin has a large capacity to make vitamin D. Exposure of a person in a bathing suit to a minimal erythemal dose of sunlight, which is typically no more than 15-20 minutes on Cape Cod in June or July at noon time, is the equivalent to taking 20,000 IU of vitamin D orally. It is now well documented that in the absence of any sun exposure 1,000 IU of vitamin D3 a day is necessary to maintain healthy levels of 25-hydroxyvitamin D in the circulation. An analysis of the NHANES III data has demonstrated that neither children nor adults are receiving an adequate amount of vitamin D from their diet or from supplements.
The DRG 25-OH Vitamin D (total) ELISAis an enzyme immunoassay for measurement of total 25-OH Vitamin D
(Vitamin D2 and Vitamin D3) in serum and plasma.
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